The Effect of Ketone Monoesters on Skeletal Muscle Protein Synthesis and Whole-body Protei
The ketone β-hydroxybutyrate (BHB) is endogenously produced during periods of low glucose availability, serving as an alternative metabolic fuel. Beyond its role as an energy substrate, BHB acts as a pleiotropic signalling molecule, modulating various physiological processes across multiple tissues. BHB can also be ing
| Condition(s) | Healthy Participants |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The ketone β-hydroxybutyrate (BHB) is endogenously produced during periods of low glucose availability, serving as an alternative metabolic fuel. Beyond its role as an energy substrate, BHB acts as a pleiotropic signalling molecule, modulating various physiological processes across multiple tissues. BHB can also be ingested orally as a ketone monoester, transiently elevating plasma concentrations of BHB to a level similar to those seen following several days of fasting, thereby obviating the need for dietary manipulation. The influence of BHB on human skeletal muscle protein metabolism remains poorly understood, although emerging evidence suggests that BHB may play a role in regulating muscle protein turnover. As such, BHB supplementation may support skeletal muscle remodelling and offer t |
| Who can participate | Inclusion Criteria: • BMI 18-30 Exclusion Criteria: * Body mass index (BMI) \< 18.5 or \> 30 kg/m2 * Age \< 18 or \> 40 * Regularly smokes * Type 2 diabetes * Cardiovascular disease, metabolic disease and hypertension (≥ 140/90 mmHg) * Gastrointestinal disorders * Use medicines that may impact protein metabolism or that are anti-inflammatory (determined at the screening) * Pregnancy |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Exeter |
| Locations | Exeter, Devon, United Kingdom |
| Start date | 2025-06-04 |
| NCT ID | NCT07082309 |
| Official listing | https://clinicaltrials.gov/study/NCT07082309 |