The Effect of Lipoprotein (a) on Arterial Stiffness, Endothelial Function and Myocardial D
1. Introduction Lipoprotein(a), or Lp(a), is a type of lipoprotein that is structurally similar to LDL (low-density lipoprotein) but carries an additional protein called apolipoprotein (a). 2. Purpose of the Study The primary purpose of this study is to investigate the effect of Lp(a) levels on arterial stiffness, endo
| Condition(s) | Lipoprotein Disorder, Arterial Stiffness, Endothelial Dysfunction |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | 1. Introduction Lipoprotein(a), or Lp(a), is a type of lipoprotein that is structurally similar to LDL (low-density lipoprotein) but carries an additional protein called apolipoprotein (a). 2. Purpose of the Study The primary purpose of this study is to investigate the effect of Lp(a) levels on arterial stiffness, endothelial function, and left atrial (LA) and left ventricular (LV) deformation over a 12-month follow-up period. Secondarily, the study will investigate: * a) The incidence of major adverse cardiovascular events (MACE), including cardiovascular death, acute myocardial infarction, and acute stroke. * b) The correlation between MACE incidence and parameters of arterial stiffness, endothelial function, and LA/LV deformation. * c) The levels of oxidative load markers. 3. Materials |
| Who can participate | Inclusion Criteria: * Adults participants 18-75 years old * Willing to sign the informed consent and paerticipate in the study Exclusion Criteria: * History of autoimmune/autoinflammatory disease, * Severe valvular heart disease, * severe chronic kidney disease(eGFR\<60 ml/min/1.73 m2), * Active Pregnancy * Severe hepatic impairment. |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Athens |
| Locations | Athens, Attica, Greece; Athens, Rimini 1, Greece |
| Start date | 2024-09-25 |
| NCT ID | NCT07324902 |
| Official listing | https://clinicaltrials.gov/study/NCT07324902 |