The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease
This study aims to evaluate the effect of 8 weeks of a stress reduction intervention on atherosclerotic plaque inflammation in adults with stable coronary artery disease, as quantified by positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in individuals with increased psychosocial stress.
| Condition(s) | Atherosclerosis, Stress, Inflammation |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | This study aims to evaluate the effect of 8 weeks of a stress reduction intervention on atherosclerotic plaque inflammation in adults with stable coronary artery disease, as quantified by positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in individuals with increased psychosocial stress. |
| Who can participate | Inclusion Criteria: * Must admit to feeling stressed and/or have PSS score \> 13 (moderate stress) * Must be willing to complete stress reduction course and imaging sessions with \< 3 missed appointments in last year * Known clinical cardiovascular disease with prior atherosclerotic myocardial infarction, percutaneous intervention or bypass surgery \> 6 months before entry, or severe coronary calcifications on computed tomography or coronary calcium score \>400 * Stable symptoms without symptomatic heart failure or arrhythmia or planned revascularization * Maximally tolerated and stable medical regimen for 90 days that does not include a high intensity statin for clinical reasons * No neurological disease or systemic inflammatory disease/current anti-inflammatory therapy * No active psychi |
| Ages | 45 Years to 65 Years |
| Sex | All |
| Lead sponsor | Massachusetts General Hospital |
| Locations | Boston, Massachusetts, United States |
| Start date | 2021-11-01 |
| NCT ID | NCT04505865 |
| Official listing | https://clinicaltrials.gov/study/NCT04505865 |