The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic hypotension. In addition to the orthostatic intolerance and tachycardia, patients with POTS experi
| Condition(s) | POTS - Postural Orthostatic Tachycardia Syndrome |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic hypotension. In addition to the orthostatic intolerance and tachycardia, patients with POTS experience several debilitating symptoms including light-headedness, nausea, blurred vision, fatigue, mental confusion ("brain-fog"), chest pain and gastrointestinal problems. Several potential underlying mechanisms have been suggested for POTS including autonomic denervation, hypovolemia, hyperadrenergic stimulation and autoantibodies against adrenergic receptors. However, none of these proposed mechanisms has yet led to an effective treatment. Physical activity is recommended as |
| Who can participate | Inclusion Criteria: * Patients diagnosed with POTS who have given written informed consent for participation in the study. Exclusion Criteria: * Patients with myalgic encephalomyelitis are excluded from the study. |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Lund University |
| Locations | Malmö, Sweden |
| Start date | 2022-11-02 |
| NCT ID | NCT05554107 |
| Official listing | https://clinicaltrials.gov/study/NCT05554107 |