The Feasibility of Pulmonary Perfusion Assessment Using Sodium Bicarbonate Contrast With E
The goal of this observational pilot study is to learn if sodium bicarbonate can be used safely and effectively as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on mechanical ventilation. Electrical impedance tomography (EIT) is a bedside imaging method that uses a soft b
| Condition(s) | Acute Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS), Pneumonia, Critical Illness, Feasibility of Contrast-enhanced Electrical Impedance Tomography (EIT) for Pulmonary Perfusion Asses |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The goal of this observational pilot study is to learn if sodium bicarbonate can be used safely and effectively as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on mechanical ventilation. Electrical impedance tomography (EIT) is a bedside imaging method that uses a soft belt with small sensors around the chest to track changes in electrical signals related to breathing and blood flow. The main questions are: Does sodium bicarbonate create clear, readable lung blood flow images with EIT? Are these images similar in quality and pattern to images made with hypertonic saline (10% sodium chloride)? Is the short-term safety profile acceptable, including effects on blood pressure, heart rhythm, and blood tests? Researchers will compare two contrast |
| Who can participate | Inclusion Criteria: * Age ≥ 18 years * Admitted to the intensive care unit (ICU) * Receiving invasive mechanical ventilation with controlled or assisted-controlled mode * Presence of a central venous catheter suitable for contrast bolus injection * Hemodynamically stable (no ongoing cardiopulmonary resuscitation; no uncontrolled shock judged by treating physician) * Expected to remain on mechanical ventilation for the duration of the EIT examination * Written informed consent obtained from the patient or legally authorized representative Exclusion Criteria: * Known pregnancy * Known allergy, intolerance, or contraindication to sodium bicarbonate or hypertonic saline * Severe arrhythmia or unstable cardiovascular status in which small bolus injection is deemed unsafe by the treating physici |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | First Affiliated Hospital of Wannan Medical College |
| Locations | Wuhu, Anhui, China |
| Start date | 2024-09-26 |
| NCT ID | NCT07542366 |
| Official listing | https://clinicaltrials.gov/study/NCT07542366 |