The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Ca
This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-
| Condition(s) | Hypotension on Induction, Cardiac Surgery, Antihypertensive Agents, Anesthesia, Intravenous, Hemodynamics |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision. |
| Who can participate | Inclusion Criteria: * Adult patients aged 40 years and older * Undergoing elective cardiac surgery (e.g., isolated CABG, isolated valve surgery, or combined CABG+valve surgery via sternotomy) * Regular use of at least one antihypertensive medication for at least 4 weeks prior to the operation date * Voluntary participation and signed informed consent Exclusion Criteria: * Emergency surgery * Preoperative shock or requirement for high-dose inotropic/vasopressor therapy * End-stage liver or kidney failure * Uncontrolled hypertension * Difficult intubation or prolonged induction process * Ejection fraction less than 35% |
| Ages | 40 Years |
| Sex | All |
| Lead sponsor | Konya City Hospital |
| Locations | Konya, Turkey (Türkiye) |
| Start date | 2026-05-01 |
| NCT ID | NCT07541222 |
| Official listing | https://clinicaltrials.gov/study/NCT07541222 |