The Role of TRP Channels in DPN
The study aims to characterize the vascular response upon topical application of cinnamaldehyde, allyl isothiocyanate and capsaicin on feet skin in healthy volunteers. The vascular response will be characterized in terms of response over time, dose-response, inter-foot and inter-period reproducibility.
| Condition(s) | Physiological Responses |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The study aims to characterize the vascular response upon topical application of cinnamaldehyde, allyl isothiocyanate and capsaicin on feet skin in healthy volunteers. The vascular response will be characterized in terms of response over time, dose-response, inter-foot and inter-period reproducibility. |
| Who can participate | Inclusion Criteria: 1. Subject is a white male or female ≥18 and ≤45 years of age 2. Subject is a non-smoker for at least 6 months prior to the start of the study 3. Subject has a body mass index (BMI) between 18-30 kg/m² 4. Subject is judged to be in good general health on the basis of medical history, physical examination and vital signs 5. Subject understands the procedures and agrees to participate in the study by giving written informed consent. Exclusion Criteria: 1. Subject has a history of any illness or disorder which, in the investigator's opinion, might confound the results of the study 2. Subject has a history of significant severe (drug) allergies 3. Subject is a female who is pregnant, breast-feeding or intends to become pregnant, or is of child-bearing potential and is not u |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Universitaire Ziekenhuizen KU Leuven |
| Locations | Leuven, Belgium |
| Start date | 2025-10-08 |
| NCT ID | NCT07237022 |
| Official listing | https://clinicaltrials.gov/study/NCT07237022 |