Threonine Requirement in Adult Males With Crohn's Disease Using IAAO
The goal of the current study is to measure the requirement for threonine in patients with CD using the IAAO method and compare the requirement to previously determined threonine requirement estimated in young adults using the IAAO technique. It is hypothesize that the requirement for threonine in patients with CD will
| Condition(s) | Crohn Disease, IBD |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The goal of the current study is to measure the requirement for threonine in patients with CD using the IAAO method and compare the requirement to previously determined threonine requirement estimated in young adults using the IAAO technique. It is hypothesize that the requirement for threonine in patients with CD will be higher than the threonine requirement previously determined in young adults using the IAAO method. Up to 10 clinically stable patients with CD will be recruited from the IBD Clinic at Mt. Sinai Hospital, Toronto, and subsequently followed up at the Clinical Research Center (CRC), The Hospital for Sick Children (SickKids), Toronto, Canada. Before the study begins, the participants will be required to visit the CRC (Room 5500 Hill Wing, The Hospital for Sick Children) for a |
| Who can participate | Inclusion Criteria: * Male 18 - 49 years of age * Having obtained his (or his legal representative's) written informed consent * Evidence of ileal and or colon inflammatory involvement and clinically stable disease state and HBI ≤ 8 * Evidence of some active disease based on history of elevated CRP or parameters of active mucosal * No evidence of intestinal strictures that may affect the subjects' ability to consume a normal diet * Have maintained a stable weight for at least 3 months and not on enteral feed via tube * Willingness to participate in the study and completed the screening procedures (height, weight, fasting blood sample and medical history questionnaire) and willingness to consume the diet provided Exclusion Criteria: * Uncontrolled inflammation which will likely require surg |
| Ages | 18 Years to 49 Years |
| Sex | Male |
| Lead sponsor | The Hospital for Sick Children |
| Locations | Toronto, Ontario, Canada |
| Start date | 2024-02-02 |
| NCT ID | NCT04740541 |
| Official listing | https://clinicaltrials.gov/study/NCT04740541 |