THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE)
Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin. They are connected to the bigger deeper veins in the leg (known as deep veins). Because of this, operations to close the varicose veins
| Condition(s) | Venous Thromboembolism, Varicose Veins |
|---|---|
| Status | Recruiting |
| Phase | Phase 4 |
| Study type | Interventional |
| Summary | Endovenous interventions are keyhole operations for varicose veins that are carried out from within the vein itself. Varicose veins are enlarged veins close to the surface of the skin. They are connected to the bigger deeper veins in the leg (known as deep veins). Because of this, operations to close the varicose veins can increase the chance of a blood clot forming in the deep veins. Blood clots in the deep veins happen in around 1 in 50 people after endovenous operations. A clot in the leg can cause swelling, pain, and other long-term problems. If a clot in the leg breaks off and travels to the lungs, it can cause problems with the lung' ability to move oxygen from the air into the blood and may, in rare cases, be life threatening. Varicose vein procedures may carry a slightly higher ris |
| Who can participate | Inclusion Criteria: * Adults (\>18 years) * Scheduled to undergo endovenous intervention of truncal varicose veins under local anaesthesia * Treatment technologies including radiofrequency, laser, mechanochemical, foam sclerotherapy and cyanoacrylate glue Exclusion Criteria: * Clinical indication for therapeutic anticoagulation e.g., atrial fibrillation * Previous personal or first-degree relative history of VTE * Thrombophilia * Female patients of childbearing potential who have a positive pregnancy test * A history of allergy to heparins or direct oral anticoagulants * A history of heparin-induced thrombocytopenia * Inherited and acquired bleeding disorders * Evidence of active bleeding * Concomitant major health problems such as active cancer and chronic renal and/or liver impairment * |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Imperial College London |
| Locations | London, United Kingdom |
| Start date | 2024-01-22 |
| NCT ID | NCT05735639 |
| Official listing | https://clinicaltrials.gov/study/NCT05735639 |