Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans. Excess morbidity and mortality during heat waves provides strong evidence for fatal outcomes. However, it is unclear why some people are particularly vulnerable and g
| Condition(s) | Skin Cancer, Heat Tolerance, Heat-related Illness, Hyperthermia, Heat Stress, Ultraviolet Radiation-Related Skin Damage |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans. Excess morbidity and mortality during heat waves provides strong evidence for fatal outcomes. However, it is unclear why some people are particularly vulnerable and get sick from hyperthermia, while others adapt and tolerate exposure. The Icarus project aims to provide a psycho-physiological framework for improved mitigation of the health threats associated with global warming. Combining expertise in integrative thermal physiology, pharmacology, photobiology, psychology and machine learning, we will collaborate on comprehensive cross-scientific studies using controlled lab-exposure combined with investigations in ecological settings inclu |
| Who can participate | Study Population Healthy adult volunteers residing in Denmark (Northern Europe) or Greece (Southern Europe). Inclusion Criteria * Age 18-65 years (or your protocol-specific age range) * Healthy as determined by medical history screening questionnaire * Able to provide written informed consent * Able to complete heat exposure and light exercise protocol * No heat acclimatization or extensive sun exposure in the previous 4 weeks * Fitzpatrick skin type I-IV (if applicable for UV testing) * Willing to undergo blood sampling, urine collection, and skin biopsy Exclusion Criteria * History of cardiovascular, metabolic, neurological, or dermatological disease * History of heat-related illness (e.g., heat stroke) * Use of medications affecting thermoregulation or cardiovascular function * Smoking |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | University of Thessaly |
| Locations | Copenhagen, Denmark; Trikala, Thessaly, Greece |
| Start date | 2025-11-01 |
| NCT ID | NCT07510061 |
| Official listing | https://clinicaltrials.gov/study/NCT07510061 |