Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis
The purpose of this randomized study will be to determine whether topical probiotic sinus irrigations are more effective compared to saline sinus irrigation controls in the treatment of active CRS in patients who have had prior sinus surgery based on subjective and objective outcome measures.
| Condition(s) | Chronic Rhinosinusitis (Diagnosis) |
|---|---|
| Status | Recruiting |
| Phase | Phase 2 |
| Study type | Interventional |
| Summary | The purpose of this randomized study will be to determine whether topical probiotic sinus irrigations are more effective compared to saline sinus irrigation controls in the treatment of active CRS in patients who have had prior sinus surgery based on subjective and objective outcome measures. |
| Who can participate | Inclusion Criteria: 1. Male and female patients 18 years of age or older. 2. Patients diagnosed with acute exacerbation of CRS, defined by worsening of 1 or more sinonasal symptoms (nasal obstruction/congestion, nasal discharge, facial pain/pressure, reduced sense of smell) and inflammatory and/or infectious changes on sinus endoscopy. 3. Patients that have undergone functional endoscopic sinus surgery \> 12 months prior to enrollment as documented in the patients electronic medical record, with patent sinuses deemed suitable for trial on investigator's discretion. 4. Patients must be willing to follow study related procedures for the duration of the study. 5. Patients must understand the purpose and procedures and be willing to sign the study informed consent document. 6. All adult men an |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | University of Illinois at Chicago |
| Locations | Chicago, Illinois, United States |
| Start date | 2025-02-05 |
| NCT ID | NCT05427695 |
| Official listing | https://clinicaltrials.gov/study/NCT05427695 |