Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinatin
Non-invasive neurostimulation can effectively improve patients' symptoms and has shown good therapeutic efficacy in alleviating the symptoms of IIDDs (Inflammatory Immune-mediated Demyelinating Diseases). However, some patients have not achieved the desired results, which may be due to individual differences in neural
| Condition(s) | Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Non-invasive neurostimulation can effectively improve patients' symptoms and has shown good therapeutic efficacy in alleviating the symptoms of IIDDs (Inflammatory Immune-mediated Demyelinating Diseases). However, some patients have not achieved the desired results, which may be due to individual differences in neural responsiveness . Therefore, this study aims to assess the therapeutic effect of transcranial electrical stimulation on improving symptoms such as painful spasm in IIDDs patients, by considering both the overall characteristics of IIDDs disease symptoms and individual differences in patients. The study will explore the imaging characteristics, electrophysiological features of the disease symptoms, and their relationship with clinical manifestations, while analyzing the key fac |
| Who can participate | Inclusion Criteria: Patients diagnosed with neuromyelitis optica spectrum disorder, multiple sclerosis, or other central nervous system inflammatory demyelinating diseases that meet the diagnostic criteria; Numeric Rating Scale (NRS) pain score ≥4; Age between 18 and 65 years, regardless of gender; Stable dose of immunosuppressive therapy for at least one month; EDSS score ≤6; Right-handed; Agree to participate and sign the informed consent form. Exclusion Criteria: A history of relapse within the past month; Recent medication adjustments or treatment with modified electroconvulsive therapy, transcranial magnetic stimulation, or other neurostimulation techniques within the past month; Participation in any other clinical trial within the past month or currently participating in another clin |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Lead sponsor | Xuanwu Hospital, Beijing |
| Locations | Beijing, China |
| Start date | 2025-05-03 |
| NCT ID | NCT06942611 |
| Official listing | https://clinicaltrials.gov/study/NCT06942611 |