Transplantation After Complete Response In Patients With T-cell Lymphoma
Peripheral T-cell lymphoma (PTCL) encompasses a broad range of post-thymic (i.e., mature) sub-entities as defined by the 2017 WHO classification. The most common entities are angioimmunoblastic T-cell lymphoma (AITL) and other Tfh-phenotype PTCL or PTCL not otherwise specified (NOS), each representing approximately 20
| Condition(s) | Peripheral T Cell Lymphoma |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Peripheral T-cell lymphoma (PTCL) encompasses a broad range of post-thymic (i.e., mature) sub-entities as defined by the 2017 WHO classification. The most common entities are angioimmunoblastic T-cell lymphoma (AITL) and other Tfh-phenotype PTCL or PTCL not otherwise specified (NOS), each representing approximately 20 to 25% of mature T- and NK/T-cell lymphomas. Compared to their B-cell counterparts, most PTCL confer dismal prognosis. In fact, except for anaplastic lymphoma kinase (ALK)-positive systemic anaplastic large cell lymphoma (sALCL), 10-year overall survival for patients with PTCL barely exceeds 30%. Given the infrequency and the heterogeneity of these malignancies, no real consensus on first-line treatment has been established for most PTCL. The place of autologous stem cell tra |
| Who can participate | Inclusion Criteria: 1. Patient ≥ 18 years and \< 70 years of age at the time of signing the informed consent form (ICF) 2. Patient fit enough to receive autologous stem cell transplant as a consolidation strategy as assessed by the local investigator 3. Hemoglobin level \> 8g/dL (transfusion allowed); Neutrophil count \>0.5 G/L; Platelets count \> 50 G/L (transfusion allowed) Patient with histologically proven "nodal-type peripheral T-cell lymphoma (PTCL)" (latest WHO classification), not previously treated; as defined by the WHO classification, the following subtypes may be included, * PTCL, not otherwise specified * Follicular helper T-cell lymphomas: Angioimmunoblastic T-cell lymphoma and nodal PTCL with TFH phenotype and follicular T-cell lymphoma * Anaplastic large cell lymphoma, ALK- |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Lead sponsor | Hospices Civils de Lyon |
| Locations | Amiens, France; Angers, France; Argenteuil, France; Avignon, France; Bayonne, France; Bordeaux, France (+42 more sites) |
| Start date | 2022-08-01 |
| NCT ID | NCT05444712 |
| Official listing | https://clinicaltrials.gov/study/NCT05444712 |