Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spast
This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities. It is designed as a prospective, cross-sectional, observational study. Planned ultrasound-based assessments include parame
| Condition(s) | Muscle Spasticity, Gait Disorders, Neurologic, Cerebral Palsy, Spastic |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities. It is designed as a prospective, cross-sectional, observational study. Planned ultrasound-based assessments include parameters such as muscle thickness, pennation angle, fascicle length, echo intensity, tissue stiffness (via shear wave elastography), and microvascular flow (via superb microvascular imaging). These measurements are intended to be compared with standard clinical evaluations, including the GMFCS, GMFM-66, MAS, MACS, and Tardieu Scale. The study seeks to contribute to a better understanding of the relationship between muscle architecture and functional outcomes, with the goal of gen |
| Who can participate | Inclusion Criteria: * Diagnosis of spastic cerebral palsy (SCP) according to the criteria defined by Rosenbaum et al. (2007) * Age between 4 and 18 years * Gross Motor Function Classification System (GMFCS) Level I, II, or III * Manual Ability Classification System (MACS) Level I, II, III, or IV Exclusion Criteria: * Non-spastic types of cerebral palsy (e.g., dyskinetic, ataxic) * Diagnosis of neuromuscular disorders other than cerebral palsy (e.g., hereditary neuropathy, myopathy) * Presence of muscle contractures or fixed deformities in the limbs selected for ultrasound and clinical assessment * Cognitive or behavioral impairments that prevent cooperation during ultrasound or clinical evaluation * Botulinum toxin-A (BoNT-A) injection applied to the target muscles within the last 6 months |
| Ages | 4 Years to 18 Years |
| Sex | All |
| Lead sponsor | Kocaeli University |
| Locations | Kocaeli, Turkey (Türkiye) |
| Start date | 2025-12-15 |
| NCT ID | NCT07118228 |
| Official listing | https://clinicaltrials.gov/study/NCT07118228 |