Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive V
Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this cognitive flexibility is human's ability to respond correctly to novel contextual situations on the first attempt, without prior rehearsal. The investigators refer to this ability as 'ad hoc self-programming':
| Condition(s) | Epilepsy |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this cognitive flexibility is human's ability to respond correctly to novel contextual situations on the first attempt, without prior rehearsal. The investigators refer to this ability as 'ad hoc self-programming': 'ad hoc' because these new behavioral repertoires are cobbled together on the fly, based on immediate demand, and then discarded when no longer necessary; 'self-programming' because the brain has to configure itself appropriately based on task demands and some combination of prior experience and/or instruction. The overall goal of our research effort is to understand the neurophysiological and computational basis for ad hoc self-programmed behavior. The previous U01 project |
| Who can participate | Inclusion Criteria: * Eligible subjects include both male and female patients, between 10 years of age and 64 years of age, who undergo placement of intracranial electrodes for clinical characterization of epilepsy. Exclusion Criteria: * Grounds for exclusion would include inability to understand and follow instructions, or inability to concentrate sufficiently to achieve a high proportion of correct responses. |
| Ages | 10 Years to 64 Years |
| Sex | All |
| Lead sponsor | Baylor College of Medicine |
| Locations | Los Angeles, California, United States; Houston, Texas, United States; Salt Lake City, Utah, United States |
| Start date | 2021-06-01 |
| NCT ID | NCT05283811 |
| Official listing | https://clinicaltrials.gov/study/NCT05283811 |