Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines
Many people, particularly small children, must take drugs in liquid form because they cannot swallow pills or capsules. The bad taste of some liquid drugs can keep patients from taking drugs they need for their health. Our main goal in this research study is find ingredients that might make drugs taste better. Particip
| Condition(s) | Healthy Adults |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | Many people, particularly small children, must take drugs in liquid form because they cannot swallow pills or capsules. The bad taste of some liquid drugs can keep patients from taking drugs they need for their health. Our main goal in this research study is find ingredients that might make drugs taste better. Participants in this research study will be healthy adults between the ages of 18 and 60 years old. Participants will taste samples (liquids or gels) containing active pharmaceutical ingredients (substances in medications that produce desired health effects). After tasting each sample participants will spit out the sample and rinse with water (no samples will be swallowed). Active pharmaceutical ingredients of current interest are: 1) tenofovir alafenamide, used to treat HIV infectio |
| Who can participate | Inclusion Criteria: * Between the ages of 18 and 60; * Generally healthy by self-report; * All races/ethnicities, both men and women; * Able to provide informed consent; * Able to attend repeated visits to Monell for sensory testing; * Willing to follow instructions (e.g., refrain from eating or drinking for at least 1 hour before sessions, willing to remain on site for one hour after tasting an API that the participant has never tasted before). - Exclusion Criteria: * Under 18 or over 60; * Pregnant, nursing, or plans to become pregnant; * Unable to provide consent (including limited ability to understand written and spoken English); * Tobacco, vape, marijuana, or tetrahydrocannabinol cartridge users. We will accept people who have used tobacco or marijuana products on occasion, but not r |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Accepts healthy volunteers | Yes |
| Lead sponsor | Monell Chemical Senses Center |
| Locations | Philadelphia, Pennsylvania, United States |
| Start date | 2025-03-18 |
| NCT ID | NCT06929455 |
| Official listing | https://clinicaltrials.gov/study/NCT06929455 |