Venous Congestion And Cognitive Dysfunction After Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after surgery and anesthesia. Its primary clinical manifestations include a significant decline in cognitive abilities after surgery and anesthesia, encompassing memory, attention, coordination, orientation, language fluency, and
| Condition(s) | Intraoperative Venous Congestion And Cognitive Dysfunction After Cardiac Surgery |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | Postoperative cognitive dysfunction (POCD) is a common central nervous system complication after surgery and anesthesia. Its primary clinical manifestations include a significant decline in cognitive abilities after surgery and anesthesia, encompassing memory, attention, coordination, orientation, language fluency, and executive function. POCD may persist for weeks or even years, affecting patient recovery, prolonging hospital stays, and potentially leading to additional physical and mental illnesses, increased mortality, and a significant burden on patients and their families. In cardiac surgery patients, the incidence of POCD ranges from 30% to 80% in the weeks following the procedure. The brain tissue is enclosed in a rigid anatomical structure; when there is an obstruction to venous re |
| Who can participate | Inclusion Criteria: 1. Patients scheduled to undergo elective cardiac surgery via a midline thoracic incision; 2. ≥18 years; 3. A preoperative MMSE score\>23, without consciousness or language barriers, capable of cooperating with neurological examinations, cognitive function tests, and other assessments of neurological function. Exclusion Criteria: 1. Contraindications for TEE; 2. Emergency cardiac surgery; 3. Major vascular surgery; 4. Redo cardiac surgery; 5. Severe infection requiring continuous antibiotic therapy; 6. Severe preoperative heart failure with left ventricular ejection fraction \< 30%; 7. A critical preoperative state (mechanical circulatory support, extracorporeal membrane oxygenation, current renal replacement therapy, mechanical ventilation, or cardiac arrest necessitat |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Zhuan Zhang |
| Locations | Yangzhou, Jiangsu, China |
| Start date | 2024-11-01 |
| NCT ID | NCT07483151 |
| Official listing | https://clinicaltrials.gov/study/NCT07483151 |