Vessel Imaging Using Optical Coherence Tomography for Plaque Morphology and Vessel Fractio
The aim of this prospective, investigator-initiated study is to evaluate the diagnostic accuracy and correlations between mopphometric indices: luminal and qualitative parameters assessed by optical coherence tomography (OCT) including minimal lumen area, plaque type, presence of thin cap fibroatheroma and a functional
| Condition(s) | Coronary Artery Disease, Coronary Artery Stenosis, Tomography, Optical Coherence, 3D-angio-based FFR |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | The aim of this prospective, investigator-initiated study is to evaluate the diagnostic accuracy and correlations between mopphometric indices: luminal and qualitative parameters assessed by optical coherence tomography (OCT) including minimal lumen area, plaque type, presence of thin cap fibroatheroma and a functional index - angiography based vessel fractional flow reserve (vFFR) among patients with chronic coronary syndrome identified with intermediate grade coronary stenosis. |
| Who can participate | Inclusion Criteria: * 18 years or older * Chronic coronary syndrome defined as presence of chest pain ranked 2-3 in the Canadian Cardiovascular Society classification or positive ischemia test (exercise test, single photon emission tomography (SPECT) * Intermediate grade coronary stenosis of 40-80% assessed visually in coronary angiography and OCT examination The patient is willing to participate in the study and has provided a written informed consent Exclusion Criteria: * Acute coronary syndrome * Proximal left main lesion * Ostial right coronary artery lesion * Bypass of the assessed vessel * Contraindications for adenosine administration * Hemodynamic instability * Heart insufficiency in New York Heart Association (NYHA) class IV scale * Acute renal insufficiency * Pregnancy |
| Ages | 18 Years |
| Sex | All |
| Lead sponsor | Medical University of Warsaw |
| Locations | Warsaw, Mazowieckie Voivodenship, Poland |
| Start date | 2020-09-20 |
| NCT ID | NCT06844942 |
| Official listing | https://clinicaltrials.gov/study/NCT06844942 |