Vietnamese Rapid Acceleration Protocol for Intensifying Drug Therapy in Heart Failure With
VN-RAPID is an open-label, multicenter, randomized controlled trial evaluating the safety and efficacy of in-hospital initiation and rapid up-titration of four-pillar therapy for hospitalized Asian patients with acute heart failure (AHF) and reduced ejection fraction (HFrEF). The study compares a standardized protocol
| Condition(s) | Acute Heart Failure (AHF), Acute Heart Failure With Reduced Ejection Fraction |
|---|---|
| Status | Recruiting |
| Phase | NA |
| Study type | Interventional |
| Summary | VN-RAPID is an open-label, multicenter, randomized controlled trial evaluating the safety and efficacy of in-hospital initiation and rapid up-titration of four-pillar therapy for hospitalized Asian patients with acute heart failure (AHF) and reduced ejection fraction (HFrEF). The study compares a standardized protocol of intensified treatment (high-intensity care arm) with usual care in patients with elevated NT-proBNP levels who are not on optimal HFrEF medications. The high-intensity care arm involves initiation of all four pillars of HFrEF therapy (RAS inhibitor, beta-blocker, MRA, and SGLT2i) before discharge, followed by a structured 6-week outpatient up-titration process with frequent follow-ups. The study aims for 75% of target doses for RAS inhibitors and beta-blockers, considering |
| Who can participate | Inclusion Criteria: 1. Hospital admission with diagnosis of acute heart failure assessed by clinical signs and symptoms of congestion and radiographic, biological tests (if admitted with acute coronary syndrome, required at least Killip class II or clear evidence of congestion on admission assessed by chest x-ray or lung ultrasound and/or pulmonary congestion requiring intravenous treatment) 2. Female or male patients ≥ 18 years old 3. At randomization: 1. Systolic blood pressure \> 90 mmHg (at least 2 measurements on 2 different occasions) and 2. Heart rate ≥ 60 bpm (at least 2 measurements on 2 different occasions) and 3. Serum potassium ≤ 5.0 mmol/L 4. Left ventricular ejection fraction (LVEF) ≤ 40% assessed locally by Simpson's Biplane method via echocardiography (if multiple LVEF m |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Lead sponsor | University Medical Center Ho Chi Minh City (UMC) |
| Locations | Long Xuyen, An Giang, Vietnam; Ho Chi Minh City, Ho Chi Minh City, Vietnam; Ho Chi Minh City, Ho Chi Minh City, Vietnam; Đông Hà, Quang Tri, Vietnam |
| Start date | 2025-08-01 |
| NCT ID | NCT06595290 |
| Official listing | https://clinicaltrials.gov/study/NCT06595290 |