Vitamin D and Endometrial Receptivity in Infertile Women
This is a prospective study comparing vaginal and endometrial biomarkers and the trophoblast spheroid attachment rate in women with fertility problems before and after taking Vitamin D for 8 weeks.
| Condition(s) | Infertility |
|---|---|
| Status | Recruiting |
| Study type | Observational |
| Summary | This is a prospective study comparing vaginal and endometrial biomarkers and the trophoblast spheroid attachment rate in women with fertility problems before and after taking Vitamin D for 8 weeks. |
| Who can participate | Inclusion Criteria: * Age of women \< 40years old * Normal uterine cavity as demonstrated by pelvic scanning with or without saline infusion sonogram or hysteroscopy * Regular ovulatory cycles They will be divided into three groups: * RIF patients (n=35)- those who have failed to get pregnant after replacing four or more cleavage stage embryos or two or more blastocysts in two consecutive transfers. * RPL patients (n=35)- those who have failed in three pregnancies before 24 weeks of gestation and includes embryonic and fetal losses. * 'Infertile group'(n=35)- infertility except RIF and RPL, e.g. those seeking for preimplantation genetic testing, male factor infertility, unexplained infertility. Exclusion Criteria: * History of any medical condition or medications that may predispose to vit |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Lead sponsor | The University of Hong Kong |
| Locations | Hong Kong, Hong Kong |
| Start date | 2021-01-15 |
| NCT ID | NCT04721899 |
| Official listing | https://clinicaltrials.gov/study/NCT04721899 |